r-u-n-n-o-f-t means: A condition in which someone has left, or been abandoned by, another person or place, sometimes abruptly under unpleasant or difficult circumstances. The colloquial spelling of “ran off” This term comes from O Brother, Where Art Thou, a movie in which a rather unskilled character wants to communicate to others that his wife has left him, but doesn’t want to speak it aloud before his son. (in Community Dictionary, added by Ryan Weiss)