John Stamos means in slang: 1. He was an actor that played Uncle Jesse in Full House between 1987-1995. His fame came from his role in a soap opera called General Hospital. Later, he appeared on a show called ER. In the 2000s, he also did some Broadway shows. 2. He is the sexiest man on earth, with a great personality and a powerful voice. (in Slang Dictionary, added by Caitlin Cline)