Gueeze means: The term originated in Southern California, in the 2000s. A Gueeze can be described as a close friend with whom you spend most of your time. The relationship may be platonic, or even romantic. One cannot just call a friend a gueeze. It is a title that has been earned through loyalty and trust. Another name for road-dog is gueeze. (in Community Dictionary, added by Keely Decker)